bioengineering of important secondary metabolites and metabolic pathways in fenugreek (trigonella foenum-graecum l.)

نویسندگان

a mehrafarin culture and research (acecr), kavosh boulevard, supa boulevard, 55th kilometer of tehran-gazvin freeway, pouleh kordan, karaj, iran tel: +98-261-4764010-19, fax: +98-261- 4764021

a qaderi department of plant biotechnology, institute of medicinal plants, acecr

sh rezazadeh department of pharmacognosy and pharmaceutics, institute of medicinal plants, acecr

h naghdi badi department of cultivation and development, institute of medicinal plants, acecr

چکیده

fenugreek (trigonella foenum-graecum l.) has a long and respected history of medicinal uses in middle east and persian medicine. the hypocholesterolaemic and hypoglycaemic effects of fenugreek were attributed to its major steroidal sapogenin, diosgenin and its major alkaloid, trigonelline. the knowledge of diosgenin and trigonelline biosynthesis is derived from studies of cholesterol and nicotinic acid production through acetyl-coa→ mevalonate→ isopentenyl pyrophosphate→ squalene→ lanosterol→ cholesterol→ diosgenin and quinolinic acid→ nicotinamide adenine dinucleotide→ nicotinamide→ nicotinic acid→ trigonelline pathways, respectively. this paper reviews the secondary metabolites and metabolic pathways of diosgenin and trigonelline production in fenugreek as a medicinal plant and economical crop.

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منابع مشابه

Bioengineering of Important Secondary Metabolites and Metabolic Pathways in Fenugreek (Trigonella foenum-graecum L.)

Fenugreek (Trigonella foenum-graecum L.) has a long and respected history of medicinal uses in Middle East and Persian medicine. The hypocholesterolaemic and hypoglycaemic effects of fenugreek were attributed to its major steroidal sapogenin, diosgenin and its major alkaloid, trigonelline. The knowledge of diosgenin and trigonelline biosynthesis is derived from studies of cholesterol and nicoti...

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فصلنامه علمی پژوهشی گیاهان دارویی

جلد ۳، شماره ۳۵، صفحات ۱-۱۸

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